Barry P Sleckman Selected Research

DNA-Activated Protein Kinase

1/2018	The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks.
2/2013	The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements.
8/2011	Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites.
6/2011	Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination.
4/2011	Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.
11/2009	Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.

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Barry P Sleckman Research Topics

Disease

17	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2018 - 07/2006
9	Neoplasms (Cancer) 10/2021 - 07/2006
9	Genomic Instability 02/2016 - 02/2002
4	Lymphopenia (Lymphocytopenia) 01/2021 - 07/2006
4	Genetic Translocation (Chromosomal Translocation) 02/2011 - 07/2006
3	Infections 01/2017 - 06/2007
3	Lymphoma (Lymphomas) 01/2014 - 10/2003
1	Breast Neoplasms (Breast Cancer) 10/2021
1	Retroviridae Infections (Infection, Retrovirus) 01/2018
1	T-Cell Lymphoma (Lymphoma, T Cell) 01/2014
1	Hypersensitivity (Allergy) 08/2012
1	Fanconi Anemia (Fanconi's Anemia) 04/2011
1	Bone Marrow Failure Disorders 04/2011
1	Chromosome Breakage 11/2009
1	Laminopathies 08/2009
1	Crohn Disease (Crohn's Disease) 11/2008
1	DNA Virus Infections 06/2007
1	Arthritis (Polyarthritis) 08/2006
1	Autoimmune Diseases (Autoimmune Disease) 10/2003
1	Leukemia 10/2003
1	Adrenal Insufficiency (Adrenal Gland Hypofunction) 10/2003
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 07/2002

Drug/Important Bio-Agent (IBA)

17	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 02/2002
13	Phosphotransferases (Kinase)IBA 01/2018 - 06/2007
7	Proteins (Proteins, Gene)FDA Link 10/2021 - 07/2002
7	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2018 - 02/2011
6	DNA-Activated Protein KinaseIBA 01/2018 - 11/2009
6	Antigen Receptors (Antigen Receptor)IBA 06/2011 - 02/2002
5	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 02/2016 - 03/2009
3	EndonucleasesIBA 02/2013 - 11/2009
3	Histones (Histone)IBA 08/2012 - 11/2008
3	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 08/2011 - 03/2009
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 08/2009 - 06/2007
2	Alanine (L-Alanine)FDA Link 06/2013 - 04/2011
1	O- (5- O- (4- coumaroyl)- alpha- arabinofuranosyl)- (1- 3)- O- beta- xylopyranosyl- (1- 4)- xylopyranoseIBA 01/2018
1	Discoidin Domain ReceptorsIBA 01/2018
1	Interleukin-18 (Interleukin 18)IBA 01/2017
1	CateninsIBA 01/2014
1	Immunoglobulin IsotypesIBA 06/2013
1	Poly Adenosine Diphosphate RiboseIBA 08/2012
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 08/2012
1	Glutamine (L-Glutamine)FDA Link 08/2011
1	Phosphatidylinositols (Phosphatidylinositol)IBA 08/2011
1	HeterochromatinIBA 08/2009
1	LaminsIBA 08/2009
1	A-Form DNA (A-DNA)IBA 11/2008
1	LeptinIBA 11/2008
1	AutoantibodiesIBA 08/2006
1	Protein Kinases (Protein Kinase)IBA 07/2006
1	GlucocorticoidsIBA 10/2003
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 10/2003
1	Peptides (Polypeptides)IBA 07/2002
1	CytokinesIBA 07/2002

Therapy/Procedure

2	Therapeutics 01/2018 - 10/2003
1	Radiotherapy 04/2016
1	Adrenalectomy 10/2003